Faktor resiko faktorfaktor yang telah diteliti sebagai faktor risiko osteoarthritis. Osteoarthritis is the most common type of joint disease, affecting more than 30 million individuals in the united states alone. Osteoarthritis causes, symptoms, diagnosis, treatment. Oarsi guidelines for the nonsurgical management of knee. Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of osteoarthritis within an experimental model. Pathophysiology of gout uric acid metabolism4,5 in humans, uric acid is the end product of purine metabolism in the liver figure 1. Until that update is published, the original recommendations from 2008 on the pharmacological management of osteoarthritis remain current advice. Pathophysiology of osteoarthritis osetoarthritis risk factors. Patofisiologi osteoarthritis oa paling sering disebabkan karena. However despite this, the incidence of osteoarthritis at the affected joint is nevertheless increased.
Accordingly, knowledge about the pathogenesis of osteoarthritis is important. Mar 15, 2014 in conclusion, osteoarthritis is a multifactorial disease of whole joint, with a complex pathomechanism involving interaction between the multiple joint tissue. In india more than 20% of total population is suffering from arthritis. It is the leading cause of activity limitation and absenteeism among workingage adults and is associated with a significant decline in function among older individuals. It is characterised pathologically by focal areas of damage to the articular cartilage, centred on loadbearing areas, associated with new bone formation at the joint margins osteophytosis, changes in the subchondral bone, variable degrees of mild synovitis, and thickening of the joint capsule. Osteoarthritis primer osteoarthritis idiopatik yaitu osteoarthritis yang kausanya tidak diketahui dan tidak ada hubungannya dengan penyakit sistemik maupun perubahan local pada sendi. Osteoarthritis oa is degenerative joint disease, which affects millions of people in the world.
Jan 01, 2012 osteoarthritis is a common degenerative disorder of the articular cartilage associated with hypertrophic bone changes. In conclusion, osteoarthritis is a multifactorial disease of whole joint, with a complex pathomechanism involving interaction between the multiple joint tissue. The conclusion from this observation is that the injury is an inciting event that commences a cascade of changes in the function of the chondrocyte that ultimately leads to its failure and the subsequent development of osteoarthritis. Radang sendi ini menimbulkan keluhan bengkak dan nyeri sendi, serta sendi terasa kaku.
Introduction the term osteomyelitis encompasses a broad group of infectious diseases characterized by. Penatalaksanaan osteoarthritis tujuan pengobatan pada pasien osteoarthritis adalah untuk mengurangi. This is accompanied by hypertrophic bone changes with osteophyte formation and subchondral bone plate thickening. Darah tepi hb, leukosit, laju endap darah dalam batas batas normal kecuali osteoarthritis generalisata yang harus dibedakan dengan artritis peradangan imayati, 2012. Kesakitan adalah simptom utama oa, melibatkan keduadua mekanisme. Osteoarthritis is a common degenerative disorder of the articular cartilage associated with hypertrophic changes in the bone. Aug 19, 2016 the contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Until recently, the focus of research into the pathophysiology of oa has been on articular cartilage and has. Lowgrade inflammation as a key mediator of the pathogenesis. Risk factors for primary oa include obesity, advancing age, female gender, and manual labour occupations. Current understanding of pathogenesis and treatment of tmj osteoarthritis x. Osteoarthritis merupakan masalah kesehatan yang sering ditemui dalam praktik seharihari. In this paper, the important molecular mechanisms related to oa pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of oa will be provided. The joint usually swells due to synovial fluid collection synovitis may occur in association with arthritis as well as lupus, gout, and other conditions.
Osteoarthritis oa is a type of joint disease that results from breakdown of joint cartilage and. Rheumatoid arthritis adalah peradangan sendi akibat sistem kekebalan tubuh yang menyerang jaringannya sendiri. Rheumatoid arthritis ra is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. Osteoarthritis is a common disorder of synovial joints. Because the precise molecular mechanisms which are involved in the. Osteoarthritis pathogenesis a complex process that involves the. Osteoarthritis pathogenesis a complex process that. Rheumatoid arthritis lebih sering diderita oleh wanita, terutama yang berusia antara 40 hingga 60 tahun, dan biasanya terjadi simetris pada sendi. Initially, osteoarthritis has been considered to be a disease of articular cartilage, but recent research has indicated that the condition involves the. Penegakan diagnosis dan penatalaksanaan yang adekuat dapat. Osteoartritis adalah penyakit sendi degeneratif yang ditandai dengan kerusakan rawan sendi dan tulang subkondral dan menyebabkan nyeri pada sendi. Osteoarthritis is the most common chronic musculoskeletal disorder. Diagnosis banding dari osteoarthritis knee yaitu penyakit sendi peradanga.
Di indonesia sendiri kasus osteoarthritis merupakan kasus penyakit reumatik yang paling sering. The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Review current concepts in the pathogenesis of osteoarthritis. Zhou1,2 abstract osteoarthritis is a common disease that can cause severe pain and dysfunction in any joint, including the temporomandibular joint tmj. Pathogenesis and clinical management of gouty arthritis. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Although the causes of osteoarthritis are diverse, mutations in type ix and xi collagens have been linked to earlyonset osteoarthritis associated with a wide range of. This leads to the hypothesis that osteoarthritis corresponds to a mechanism of bone healing in the wrong place. Mcmaster osteoarthritis index womac merupakan kuesioner spesifik untuk menilai nyeri, kekakuan sendi dan kapasitas fungsi pada pasien. It is characterized by persistent inflammation that primarily affects the peripheral joints. Dipercayai bahwa sel t adalah pencetus dalam proses pathogenesis rheumatoid arthritis. Pathophysiology of osteoarthritis osteoarthritis and. Osteoarthritis oa and rheumatoid arthritis ra are two. There are a variety of factors that play an important role in the pathogenesis of oa, including biomechanical factors, proinflammatory mediators, and proteases.
A key role in the pathophysiology of articular cartilage is played by cell. Common in weightbearing joints such as hip and knee. Sports injuries and certain occupations farmers may increase risk of developing osteoarthritis. Osteoarthritis includes a slow but efficient repair process that often. Osteoarthritis oa is a complex disease whose pathogenesis includes the contribution of biomechanical and metabolic factors which, altering the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive over productive processes. Osteoarthritis oa is a disease of high prevalence that produces substantial morbidity and is a leading cause of physical and psychological disability and expense, includ ing time lost from work, medical care, and disability sup port. Osteoarthritis is a disease in which the articular cartilage degenerates over time, causing pain and inflammation in the affected joint.
The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of. This article compares the mechanism of secondary bone healing with that of osteoarthritis, and can show clear parallels based on numerous study findings. Osteoarthritis osteoarthritis is a noninflammatory, degenerative condition of joints characterized by degeneration of articular cartilage and formation of new bone i. The condition is usually painful, particularly when the joint is moved. Pathophysiology and pathogenesis of osteomyelitis 5 fig. Osteoartritis oa merupakan penyakit sendi degeneratif kronik non. Sel t kemudian bermigrasi menuju jaringan synovial, lebih lanjut lagi. Jul 06, 2010 research in both mice and humans on the pathogenesis of osteoarthritis oa has begun to coalesce recently. Pathophysiology of osteoarthritis osetoarthritis risk. The special issue will be guest edited by ewa roos, mayarna risberg and christopher little. Osteoarthritis sekunder adalah osteoarthritis yang didasari adanya kelainan endokrin, inflamasi, metabolic, pertumbuhan, herediter, jejas mikro dan makro.
Research in both mice and humans on the pathogenesis of osteoarthritis oa has begun to coalesce recently. Osteoarthritis oa is a chronic degenerative disorder of multifactorial. Pathogenesis and management of pain in osteoarthritis. Western ontario and mcmaster universities osteoarthritis index. Epidemiological studies estimate around 43 million affected patients in the united states alone and about 15% of the world population 1, 2, 3. The pathophysiology of osteoarthritis sciencedirect. Oarsi guidelines for the nonsurgical management of knee osteoarthritis t. Knowledge of the etiopathogenesis of oa has progressed significantly in the past few decades. Clinical and imagenological diagnosis, pathogenic role of the immuno inflammatory response, and. Menerima terapi manual dikombinasi dengan latihan yang. Knowing of this complex process of producing osteoarthritis is essential for development of new methods of diagnostic and treatment. Osteoarthritis merupakan suatu kelainan degerasi sendi yang terjadi. The new england journal of medicine n engl j med 365. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent.
Osteoarthritis oa is a common debilitating joint disorder, affecting large. Rheumatoid arthritis gejala, penyebab dan mengobati alodokter. Hip osteoarthritis has a significant genetic component. Affected horses typically have clinical evidence of synovitis, varying degrees of lameness, and progressive loss of joint function. Rheumatoid arthritis gejala, penyebab dan mengobati. Conroy 2 1university of texas health science centre, san antonio, texas 2harrogate district hospital, north yorkshire 1usa 2uk 1. Van ryssen b, vanbree h, dimoens p 1993 elbow arthroscopy in clinically normal dogs. This type of spinal infection is seen more commonly in children. Th e lack of normal disc signal at the circled segment black arrow represents infection. Diagnosis dilakukan dengan melakukan anamnesis seksama serta. Osteoarthritis oa is characterized by a degeneration of articular cartilage, in which the breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness loss of the joint surface. Osteoarthritis is a chronic, inflammatory joint disease in the world. During the last decade, there have been significant advances in our understanding of the pathophysiology of oa.
Rheumatoid arthritis introduction rheumatoid arthritis ra is a chronic, progressive autoimmune disease of unknown cause. This membrane lines joints that possess cavities, known as synovial joints. It is a complex disease whose pathogenesis, changes the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive processes. Osteoarthritis is characterised pathologically by localised loss of cartilage, remodelling of adjacent bone and associated inflammation. Kerusakan kartilago adalah proses patognomonikhallmark process yang. Osteoarthritis oa in horses is a chronic, degenerative process. Osteoarthritis merupakan kelainan pada sendi ditandai dengan. Rheumatoid arthritis ra is regarded as a sys temic autoimmune. Osteoarthritis oa is a disease that predominantly, but not solely, affects the diarthrodial joints and results from an interaction between a number of complex mechanical and biological processes. The pathophysiology of osteoarthritis springerlink.
Joint disorders at merck manual of diagnosis and therapy professional edition. Osteoarthritis pathogenesis a complex process that involves. Pathogenesis of rheumatoid arthritis thermo fisher. Molecular pathogenesis of osteoarthritis a series of lunch time seminars sponsored by the biochemical society mayjune 2016. It can be thought of as primarily a degenerative disorder with inflammatory components arising from the biochemical breakdown of articular hyaline. A key role in the pathophysiology of articular cartilage is played by cellextracellular matrix ecm interactions. Risk factors include genetics, female sex, past trauma, advancing age, and. Basic information about osteoarthritis, a common form of arthritis that affects adults. It represents a heterogeneous group of conditions resulting in common histopathologic and radiologic changes. Osteoarthritis oa merupakan jenis gangguan persendian yang paling sering dijumpai cote. Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan, implications for pathogenesis. However, the pathogenesis of oa is much more complex than just wear and tear and the term osteoarthritis, where itis is indicative of an inflammatory process, is indeed correct. A variety of traumas may trigger the need for a joint to repair itself.
Oa pathogenesis, biomarkers and treatment has broadened immensely in recent years. In children, bone growth occurs through extension of cartilage at the growth plate combined with conversion of cartilage to bone at the junction point endochondral ossification. In india more than 20% of total population is suffering from arthritis, although the main cause of disease is unknown. Osteoarthritis, the most common form of human arthritis, consists of a group of overlapping diseases with different etiologies but similar clinical outcomes.
The pathogenesis of oa involves a degradation of cartilage and remodelling of bone due to an active response of chondrocytes in the articular cartilage and the inflammatory cells in the surrounding tissues. Osteoarthritis and cartilage would like to invite contributions to a special issue on oa prevention. Osteoarthritis is traditionally thought of as a wear and tear disease which occurs as we age. Full details and instructions for submission can be found here pdf. The pathogenesis of a disease is the biological mechanism or mechanisms that leads to a diseased state. Adanya interaksi antara sel t dan dendritic sel pada kelenjar limfe akan mengaktifasi lebih jauh sel t dan menyebabkan peningkatan populasi sel t dan kemudian akan mengaktifkan sel b. Osteoarthritis oa, the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Patofisiologi osteoarthritis oa paling sering disebabkan karena penuaan sendi secara fisiologis, sehingga sering kali disebut dengan penyakit sendi degeneratif. Oct 10, 20 osteoarthritis oa is a complex disease whose pathogenesis includes the contribution of biomechanical and metabolic factors which, altering the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive over productive processes. Synovitis is the medical term for inflammation of the synovial membrane.
Lameness is the main cause of consultation in the current equine clinic, and osteoarthritis oa represents about 60% of cases. Uric acid excretion humans lack the enzyme uricase, which degrades uric acid to highly soluble allantoin. Arthritis affects one in six new zealanders over the age of 15 years. Osteoarthritis can occur at any age, but usually starts after the age of 40. Osteoarthritis merupakan kelainan sendi degenerasi non inflamasi yang terjadi pada. Osteoartritis diketahui dialami sepertiga populasi di atas usia 65 tahun dan merupakan. Untuk osteoarthritis, beberapa kajian telah menganalisis ambang kesakitan dan. The word comes from the greek pathos suffering, disease and. Osteoarthritis is the most common type of joint disease, affecting more than 20 million individuals in the united states alone see epidemiology. Osteoarthritis oa of the knee is a major cause of pain and locomotor disability worldwide.
Diagnosis and management of rheumatoid arthritis amy m. Pdf osteoarthritis is a chronic, inflammatory joint disease in the world. Highlights the differences in the pathophysiology and diag. Osteoarthritis oa is a longterm chronic disease characterized by the deterioration of cartilage in.